Voltage-Clamp Studies on Uterine Smooth Muscle

Voltage-Clamp Studies on Uterine Smooth Muscle

These studies have developed and tested an experimental approach to the study of membrane ionic conductance mechanisms in strips of uterine smooth muscle. The experimental and theoretical basis for applying the double sucrose-gap technique is described along with the limitations of this system. Nonpropagating membrane action potentials were produced in response to depolarizing current pulses un...

Studies on Calcium and Sodium in Uterine Smooth Muscle Excitation under Current-Clamp and Voltage-Clamp Conditions

The objective of these studies was to define the roles of calcium and sodium in uterine smooth muscle excitation. The double sucrose-gap technique was used for current-clamp and voltage-clamp experiments. It was shown that neither sodium nor calcium alone is capable of supporting excitation in estrogen-dominated uterine smooth muscle. Calcium dependence was explained in part by increased membra...

Voltage Clamp Studies o f the Hyperpolarizing Inactivation in Intestinal Smooth Muscle Cell

Voltage Clamp Studies on Internally Perfused Axons

Probably the most striking and surprising observation in internally perfused axons is that full-sized action potentials can be obtained in the face of a very low resting potential when the ionic strength is low In all experiments at normal ionic strength known to the author, the explosive all-or-none responsiveness was lost when the internal and/or external monovalent cations were arranged to g...

The effect of aqueous extract of pomegranate seed on rat uterine smooth muscle contractility

Introduction: Considering the importance of uterine contractions in uterus retraction and reducing post-partum hemorrhage and the current findings on the effect of the alcoholic extract of pomegranate seed on the uterine contractility, only few studies were made on this issue. In the present study the cumulative effect of the aqueous extract of pomegranate seed on the uterine smooth muscle c...